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Teeth

Teeth

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Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

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Familial Hypodontia: A Case Series.

S P Tangade¹, T L Ravishankar¹, M Batra¹

¹Department of Public Health Dentistry Kothiwal Dental College & Research Centre, Kanth Road, Moradabad-244001, Uttar Pradesh, India.

Kathmandu University Medical Journal (KUMJ)

|December 9, 2015

Summary

This study details non-syndromic familial hypodontia in siblings, a condition of congenitally missing teeth. The cases highlight the genetic basis of dental agenesis and its impact on occlusion and aesthetics.

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Area of Science:

Dentistry
Genetics
Human Biology

Background:

Congenitally missing teeth, also known as dental agenesis, is a common developmental anomaly with various classifications including hypodontia and oligodontia.
Familial occurrence suggests a genetic predisposition to this condition.
Non-syndromic forms are distinguished from those associated with broader genetic syndromes.

Observation:

Two siblings from the same family presented with hypodontia.
Case I exhibited absence of teeth 18, 12, 22, and 31.
Case II showed absence of teeth 31 and 41.

Findings:

The diagnosis of non-syndromic familial hypodontia was established based on the affected siblings and the absence of syndromic features.
Both siblings presented with dental agenesis, resulting in malocclusion and aesthetic concerns.
The familial pattern indicates a hereditary component in the development of hypodontia.

Implications:

Understanding the genetic basis of non-syndromic familial hypodontia is crucial for genetic counseling and risk assessment.
Early diagnosis and intervention are essential to manage malocclusion and aesthetic disturbances.
An interdisciplinary dental approach is recommended for comprehensive treatment planning and management of affected individuals.