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Updated: Mar 29, 2026

Author Spotlight: Time and Cost-Effective Fibrinogen-PAGE for Fibrinogenolytic Studies
Published on: April 19, 2024
Diagnostic value of serum fibrinogen as a predictive factor for complicated appendicitis (perforated). A
F A Alvarez-Alvarez1, V M Maciel-Gutierrez2, A D Rocha-Muñoz3
1Department of General Surgery, Hospital Civil de Guadalajara, "Dr. Juan I. Menchaca", University of Guadalajara, Salvador de Quevedo no. 750, Guadalajara, Jalisco, Zip code 44100, Mexico.
Background:
Acute appendicitis (AA) has a prevalence of 8% in the general population with a rate of complicated (perforated) appendicitis (CA) up to 40%. Serum fibrinogen may serve as an indicator for CA.
Patients And Methods:
115 patients were included from January 2012 to December 2012 using a positive pathology report for AA as a gold standard diagnostic method. We divided the patients into two groups accordingly to the pathology report: Complicated Appendicitis and Uncomplicated Appendicitis (UA). Our primary endpoint was to compare the levels of serum fibrinogen between the two groups and find if there is a relationship between fibrinogen level and CA.
Results:
68 patients were diagnosed with UA and 47 with CA. Using a fibrinogen value of 885 mg/dl we found to be the best cut-off for predicting complicated appendicitis with a sensitivity of 86.77% (76.87-93.71 IC 95%), a specificity of 91.49 (83.51-99.46 IC 95%), a positive predictive value of 93.65 (95% CI 86.81-99.64) and, a negative predictive value of 82.69 (95% CI 65.73-87.84).
Conclusion:
In the setting of a patient with a clinical diagnosis of AA, this study demonstrates fibrinogen as a good predictor factor for appendiceal perforation.
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