Polymorphism in the RASGRF1 gene with high myopia: A meta-analysis

Area of Science:

• Genetics
• Ophthalmology
• Population Studies

Background:

• High myopia is a significant public health concern with complex genetic underpinnings.
• The RASGRF1 gene has been implicated in various biological processes, but its specific role in high myopia requires further investigation.
• Understanding genetic associations can inform preventative strategies and personalized treatments for high myopia.

Purpose of the Study:

• To evaluate the association between the RASGRF1 rs8027411 polymorphism and high myopia.
• To assess this association specifically within Chinese and Japanese populations.

Main Methods:

• A systematic literature search was conducted across major databases (PubMed, EMBASE, Cochrane Library, Web of Science, China Biologic Medical Database).
• A meta-analysis was performed on data from four studies, including 2,529 high myopia cases and 3,127 controls.
• Pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated, with heterogeneity and publication bias assessed.

Main Results:

• The RASGRF1 rs8027411 polymorphism was significantly associated with high myopia in Chinese and Japanese populations.
• Carriers of the G allele showed a lower risk of high myopia compared to T allele carriers (G vs T, OR=0.83, 95% CI=0.77-0.89).
• Subgroup analyses indicated a more prominent protective effect of the G allele in Chinese populations across various genetic models.

Conclusions:

• The rs8027411 G allele in the RASGRF1 gene may confer a protective effect against high myopia in Asian populations.
• The RASGRF1 gene is a potential factor in the development of high myopia, especially in East Asian individuals.
• Further research is warranted to validate these findings and explore the functional mechanisms involved.