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Updated: Mar 29, 2026

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
Published on: May 6, 2018
Emerging Agents for the Management of Nephrotic Syndrome: Progress to Date
Keisha L Gibson1, Panupong Hansrivijit2, Maria E Ferris3
1University of North Carolina Kidney Center at Chapel Hill, 7005 Burnett Womack, Chapel Hill, NC, 27599-7155, USA. kgibson@med.unc.edu.
Abstract:
Nephrotic Syndrome is a rare condition associated with high morbidity in the 20-40% of children and adolescents who fail to respond to standard immunosuppressive therapies. Novel non-immunologic mechanisms of widely used immunosuppressive therapies, as well as emerging anti-inflammatory drugs, and anti-fibrotics may play a crucial role in the treatment of patients with refractory disease. This article will review some of these treatments and their various stages of investigation.
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