Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

No evidence for depletion of circulating lymphocyte populations in primary brain tumor patients receiving radiotherapy alone.

International journal of radiation oncology, biology, physics·2026

Same author

Impact of ataxia-telangiectasia mutated (ATM) loss on radiobiological and immune response to radium-223 in prostate cancer <i>in vitro</i> models.

Clinical and translational radiation oncology·2026

Same author

Monte Carlo in radiation therapy as physics in medicine & biology marks its seventieth anniversary.

Physics in medicine and biology·2026

Same author

Modeling variable interactions using Bayesian networks to identify direct predictors of radiation-induced optic neuropathy after proton therapy: implications for personalized toxicity risk stratification.

Physics in medicine and biology·2026

Same author

Technical Considerations on Proton Therapy in NRG's Multi-Institutional Clinical Trials.

International journal of radiation oncology, biology, physics·2026

Same author

Ultra-high dose rate dependent modeling of plasmid DNA damage with TOPAS-nBio.

Physics in medicine and biology·2026

Same journal

Lasing characteristics and stress-tuning effects in GaN beam microcavities.

Nanoscale·2026

Same journal

Unraveling the synergy of core doping and the motif shell in atomically precise PtAg nanoclusters for CF<sub>3</sub>-ketone alkynylation.

Nanoscale·2026

Same journal

A dual-functional heavy-metal-free quantum dot/TiO<sub>2</sub> hybrid system for simultaneous pollutant degradation and green hydrogen production.

Nanoscale·2026

Same journal

Rational design of spherical NiCoB@rGO nanocomposites for efficient electrochemical energy storage.

Nanoscale·2026

Same journal

Ligand-controlled engineering of Cu-H active sites on Cu<sub>25</sub> hydride nanoclusters for efficient CO<sub>2</sub> electroreduction.

Nanoscale·2026

Same journal

Isostructural Co/Ni-containing banana-shaped polyoxometalates for visible-light-driven hydrogen production.

Nanoscale·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 29, 2026

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay

Published on: February 28, 2015

Optimising element choice for nanoparticle radiosensitisers.

Stephen J McMahon¹, Harald Paganetti², Kevin M Prise³

¹Department of Radiation Oncology, Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA and Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, UK. stephen.mcmahon@qub.ac.uk.

|December 10, 2015

Summary

This summary is machine-generated.

Heavy atom nanoparticles show promise as theranostic agents. Their radiation dose enhancement varies with atomic number, impacting biological effectiveness and guiding future clinical applications.

More Related Videos

Optimization of Radiochemical Reactions using Droplet Arrays

Optimization of Radiochemical Reactions using Droplet Arrays

Published on: February 12, 2021

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Published on: June 23, 2020

Related Experiment Videos

Last Updated: Mar 29, 2026

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay

Published on: February 28, 2015

Optimization of Radiochemical Reactions using Droplet Arrays

Optimization of Radiochemical Reactions using Droplet Arrays

Published on: February 12, 2021

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Published on: June 23, 2020

Area of Science:

Medical Physics
Nanotechnology
Radiotherapy

Background:

Heavy atom nanoparticles offer high radiation cross-sections for theranostic applications.
Research has predominantly focused on gold nanoparticles, necessitating broader material investigation.

Purpose of the Study:

To evaluate macro- and micro-scale radiation dose enhancement of heavy atom nanoparticles (Z > Si) using X-ray irradiation.
To assess potential biological impacts using the Local Effect Model.

Main Methods:

Monte Carlo radiation transport modeling with Geant4.
Analysis of nanoparticles with stable elements heavier than silicon.
Application of the Local Effect Model for biological impact assessment.

Main Results:

Macroscopic dose enhancement is predictable by absorption cross-sections.
Nanoscale dose deposition shows complex atomic number dependency, with peaks at Germanium (Z=32) and Gadolinium (Z=64).
Variations in secondary Auger electron spectra drive differences in biological effectiveness.

Conclusions:

Atomic number significantly influences nanoscale dose deposition and biological effectiveness of heavy atom nanoparticles.
These findings aid in predicting and understanding theranostic agent mechanisms for clinical use.