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[PSI(+)] turns 50.

Mick F Tuite1, Gemma L Staniforth1, Brian S Cox1

  • 1a Kent Fungal Group; School of Biosciences; University of Kent ; Canterbury , Kent , UK.

Prion
|December 10, 2015
PubMed
Summary
This summary is machine-generated.

This review details the evolution of understanding yeast prion biology, specifically the [PSI(+)] determinant. It highlights its transformation into a transmissible amyloid form and its impact on prion research.

Keywords:
Brian Cox[PSI+] prionnon-Mendelian inheritancenonsense suppressionprionyeast

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Area of Science:

  • Fungal Biology
  • Molecular Biology
  • Prion Research

Background:

  • The [PSI(+)] determinant in yeast is crucial for understanding prion biology.
  • Brian Cox's 1965 paper on 'ψ' laid the foundation for this field.
  • Fifty years later, the molecular nature of [PSI(+)] is better understood.

Purpose of the Study:

  • To trace the evolution of understanding the [PSI(+)] determinant.
  • To discuss the impact of [PSI(+)] research on the broader field of prions.
  • To gather commentaries from leading investigators on [PSI(+)]'s significance.

Main Methods:

  • Review of historical research on the [PSI(+)] determinant.
  • Analysis of the transition from 'occult' to amyloid form.
  • Inclusion of expert commentaries from yeast prion researchers.

Main Results:

  • The [PSI(+)] determinant is now understood as a transmissible amyloid form of a translation termination factor.
  • Studies on [PSI(+)] have significantly advanced prion research.
  • Expert insights underscore the discovery and importance of [PSI(+)].

Conclusions:

  • The understanding of yeast prions, particularly [PSI(+)], has progressed significantly.
  • [PSI(+)] research continues to be a vital area, influencing prion studies.
  • The historical and ongoing impact of [PSI(+)] on prion science is substantial.