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Related Concept Videos

Cross-bridge Cycle01:26

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As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
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Related Experiment Video

Updated: Mar 29, 2026

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
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ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

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[Amyotrophic lateral sclerosis. Multisystem degeneration].

A Hübers1, A C Ludolph1, A Rosenbohm1

  • 1Klinik für Neurologie, Universitätsklinikum Ulm, Universität Ulm, Oberer Eselsberg 45, 89081, Ulm, Deutschland.

Der Nervenarzt
|December 10, 2015
PubMed
Summary
This summary is machine-generated.

Amyotrophic lateral sclerosis (ALS) is increasingly recognized as a multisystem degeneration, not just a motor neuron disease. Nonmotor symptoms and neuropathological findings offer new diagnostic and therapeutic insights.

Keywords:
Amyotrophic lateral sclerosisDNA-binding proteinsMotor neuron diseaseNervous system diseasesProtein TDP-43

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Area of Science:

  • Neurology
  • Neuroscience

Background:

  • Amyotrophic lateral sclerosis (ALS) is increasingly understood as a multisystem neurodegenerative disorder.
  • Evidence suggests ALS involves nonmotor symptoms beyond classic motor neuron degeneration.

Purpose of the Study:

  • To review current findings supporting ALS as a multisystem degeneration.
  • To explore implications for ALS diagnostics and therapeutic strategies.

Main Methods:

  • Review of recent clinical data.
  • Analysis of neuroimaging findings.
  • Examination of neuropathological studies.

Main Results:

  • ALS presents with motor, cognitive, oculomotor, extrapyramidal, and sensory symptoms.
  • Neuropathological studies reveal systematic spreading of transactive response DNA binding protein 43 kDa (TDP-43).

Conclusions:

  • Nonmotor symptoms are common in ALS, though often subtle.
  • Neuropathological findings provide novel avenues for ALS diagnosis and treatment.