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Published on: March 21, 2017
How hematopoietic stem/progenitors and their niche sense and respond to infectious stress
Hiroshi Kobayashi1, Toshio Suda2, Keiyo Takubo1
1Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Abstract:
Hematopoietic stem/progenitor cells (HSPCs) play important roles in fighting systemic infection as they supply immune cells in a demand-adapted manner. Various mechanisms govern HSPC responses to infection, including cytokine signaling, niche function, and direct sensing of pathogen-derived molecules by HSPCs themselves. Here we review recent advances in our understanding of HSPC responses to infection and also consider newly identified STING-mediated machinery recognizing bacteria-derived cyclic dinucleotides.
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