Pseudoprogression: Patient experience and nursing in uncertainty

Area of Science:

• Neuro-oncology
• Radiology
• Patient Experience

Background:

• Glioblastoma Multiforme (GBM) is an aggressive brain cancer with poor prognosis.
• Treatment focuses on supportive care, not cure, leading to patient uncertainty.
• Imaging can show apparent progression (Pseudoprogression or PsP) that may improve over time.

Purpose of the Study:

• To review the literature on Pseudoprogression (PsP) in high-grade gliomas.
• To explore the patient and family experience of PsP using established theories and practical insights.
• To propose nursing implications for managing PsP in neuro-oncology.

Main Methods:

• Literature review on Pseudoprogression in high-grade gliomas.
• Application of Mishel's Uncertainty in Illness Theory.
• Integration of research on neuro-oncology patient/family experiences and nursing practice.

Main Results:

• Pseudoprogression (PsP) presents as apparent tumor progression on imaging, which can stabilize or resolve.
• Patient and family uncertainty is heightened by imaging findings suggestive of progression.
• Understanding PsP is vital for accurate interpretation of treatment effects and patient counseling.

Conclusions:

• Pseudoprogression (PsP) is a significant factor influencing the experience of patients with high-grade gliomas.
• Addressing patient and family uncertainty related to PsP is a key nursing role.
• Further research and clinical guidelines are needed to optimize management of PsP.