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Updated: Mar 29, 2026

Rapid Identification of Gram Negative Bacteria from Blood Culture Broth Using MALDI-TOF Mass Spectrometry
Published on: May 28, 2014
Discrimination between bacterial species by ratiometric analysis of their carbohydrate binding profile
Lucienne Otten1, Elizabeth Fullam2, Matthew I Gibson1
1Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. m.i.gibson@warwick.ac.uk.
Abstract:
Antibiotic resistance is a global health concern meaning there is an urgent need for new treatments and diagnostics. Here glycosylated surfaces are used to profile the binding patterns of a range of Gram-negative, Gram-positive and mycobacteria. This enables the creation of 'barcodes' to enable identification and discrimination between the strains, which could not be achieved by single-point glycan binding and offers a new concept in bacteria detection.
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