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Related Concept Videos

Sensitivity, Specificity, and Predicted Value01:13

Sensitivity, Specificity, and Predicted Value

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In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
Sensitivity is the...
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Author Spotlight: Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment
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[Immunoscore and Its Predictive Value for Colorectal Cancer].

E Závadová, J Špaček, M Vočka

    Klinicka Onkologie : Casopis Ceske a Slovenske Onkologicke Spolecnosti
    |December 10, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Immune scoring (immune-score) shows prognostic value superior to TNM staging in cancer patients. High T-lymphocyte density in tumors correlates with better survival and lower relapse risk, suggesting its diagnostic potential.

    Keywords:
    immunoscore -  TNM -  VEGF -  TGFβ -  CD3+ lymphocytes -  CD8+ lymphocytesThis project was supported by AZV CR 15-28188Aor services used in the study.The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers.Submitted: 4. 8. 2015Accepted: 13. 9. 2015.productsthe League Against Cancer and PRVOUK-P-27//LF1/1.The authors declare they have no potential conflicts of interest concerning drugs

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    Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing
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    Area of Science:

    • Oncology
    • Immunology
    • Cancer Diagnostics

    Context:

    • Clinical outcomes vary significantly within the same TNM stage, indicating limitations of current cancer staging.
    • Tumor microenvironment and immune cell infiltration are critical factors influencing cancer progression and patient prognosis.
    • Existing TNM classification may not fully capture the prognostic variability observed in cancer patients.

    Purpose:

    • To evaluate the prognostic value of Immunoscore methodology in a large cohort of colorectal cancer patients.
    • To assess the correlation between immune cell infiltration (CD8+, CD3+ lymphocytes) and patient outcomes, including treatment response, progression, and survival.
    • To determine if Immunoscore can provide superior prognostic information compared to the AJCC/UICC TNM classification.

    Summary:

    • Immunoscore quantifies immune cell density and localization within tumor tissue and the invasive margin.
    • An international collaboration involving over 7,000 colorectal cancer patients is evaluating Immunoscore.
    • Inverse correlation observed between T-lymphocyte density (CD8+, CD3+) and tumor stage; higher densities are linked to better survival, reduced relapse, and fewer metastases.

    Impact:

    • High T-lymphocyte infiltration in tumors is associated with significantly longer asymptomatic survival and overall survival.
    • Immunoscore has the potential to refine cancer prognostication beyond TNM staging.
    • The findings support the integration of Immunoscore into routine cancer diagnostics for improved patient management.