Targeting Transient Receptor Potential Canonical Channels for Diseases of the Nervous System
Yibin Wang, Jiyuan Bu, Haitao Shen
1Department of Neurosurgery, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, China.
Transient receptor potential canonical (TRPC) channels are vital for nervous system functions and diseases. This review highlights TRPC channels
Area of Science:
- Neuroscience
- Physiology
- Pathophysiology
Background:
- Calcium ion (Ca2+) influx is crucial for nervous system functions and diseases.
- Transient receptor potential canonical (TRPC) channels are voltage-sensitive calcium channels.
- TRPC channels are highly expressed in the central nervous system (CNS).
Purpose of the Study:
- This review discusses the importance of TRPC channels.
- It examines the role of TRPC channels in the pathogenesis of various nervous system diseases.
Main Methods:
- Literature review of TRPC channel function and involvement in neurological diseases.
Main Results:
- TRPC channels are implicated in cerebral vasospasm after subarachnoid hemorrhage.
- They are involved in neuronal damage after intracerebral hemorrhage and NMDA cytotoxicity in cerebral ischemia.
- TRPC channels are associated with nervous system tumors, neurodegenerative diseases, and neural addiction.
Conclusions:
- The TRPC family exhibits diverse functionality and widespread distribution.
- TRPC channels play varied roles in different nervous system diseases.
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