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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
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An Overview of Emerging Immunotargets of Genitourinary Tumors

Rodolfo Montironi, Matteo Santoni, Liang Cheng

  • 1Medical Oncology, Azienda Ospedaliera Universitaria Integrata, University of Verona, Piazzale L.A. Scuro 10, 37124 Verona, Italy. fmassari79@gmail.com.

Current Drug Targets
|December 10, 2015
PubMed

Insights

Emerging immunotherapies show promise for genitourinary cancers like prostate (PCa), bladder (BC), and renal cell carcinoma (RCC). Understanding immune cell roles is key to integrating these treatments effectively.

Area of Science:

  • Oncology
  • Immunology
  • Urology

Background:

  • Genitourinary tumors, including prostate cancer (PCa), bladder cancer (BC), and renal cell carcinoma (RCC), are increasingly being treated with novel immunotherapies.
  • These therapies target immune checkpoints and tumor-associated antigens, offering new treatment avenues.

Purpose of the Study:

  • To provide an overview of recent insights into the role of immune cells in genitourinary tumors.
  • To explore the potential integration of immunotherapies into current treatment strategies.

Main Methods:

  • This review synthesizes current literature on the immunobiology of genitourinary cancers.
  • It focuses on the involvement of neutrophils, T and B lymphocytes, and tumor-associated macrophages (TAMs).

Main Results:

  • Immune cells, including neutrophils, lymphocytes, and TAMs, play significant roles in the pathogenesis and progression of genitourinary tumors.
  • These cells are implicated in cancer-related immunosuppression and the development of drug resistance.

Conclusions:

  • A deeper understanding of the immune system's protumorigenic activity and immunosuppression mechanisms is crucial for optimizing immunotherapy in genitourinary cancers.
  • Effective integration of immunotherapies, potentially in sequential or combined approaches, hinges on this comprehensive knowledge.

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