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Sendai virus as a backbone for vaccines against RSV and other human paramyxoviruses

Charles J Russell1,2, Julia L Hurwitz1,2

  • 1a Department of Infectious Diseases , St. Jude Children's Research Hospital , Memphis , TN , USA.

Expert Review of Vaccines
|December 10, 2015
PubMed

Insights

Sendai virus shows promise as a potential vaccine for human parainfluenza virus type 1 and as a foundation for vaccines against respiratory syncytial virus and human metapneumovirus in children.

Area of Science:

  • Virology
  • Vaccinology
  • Pediatric infectious diseases

Background:

  • Human paramyxoviruses cause severe respiratory infections in infants and children globally.
  • Respiratory syncytial virus (RSV), human parainfluenza viruses (hPIVs), and human metapneumovirus (hMPV) are major pediatric pathogens.
  • Current therapeutic and preventative options for these viral infections are limited.

Purpose of the Study:

  • To review the potential of Sendai virus as a vaccine candidate.
  • To explore Sendai virus as a platform for developing new vaccines against pediatric paramyxoviruses.

Main Methods:

  • Review of existing research on Sendai virus and its application in vaccinology.
  • Analysis of Sendai virus's suitability as a Jennerian vaccine for hPIV1.
  • Evaluation of Sendai virus as a vaccine backbone for RSV, hMPV, and other hPIVs.

Main Results:

  • Sendai virus is being developed as a Jennerian vaccine for human parainfluenza virus type 1.
  • Sendai virus serves as a potential vaccine backbone for respiratory syncytial virus, human metapneumovirus, and other human parainfluenza viruses.

Conclusions:

  • Sendai virus represents a promising candidate for pediatric respiratory virus vaccines.
  • Further research into Sendai virus-based vaccines could address unmet needs in preventing serious childhood respiratory infections.
Keywords:
Sendai virusT cellantibodyintranasalparamyxoviruspediatric vaccinerespiratory tractvaccine vector

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