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A powerful inhibitor of guanine deaminase
The Italian Journal of Biochemistry
|January 1, 1977
Abstract:
The synthesis of 9-(p-carbetoxyphenyl) guanine is reported. The assays carried out on guanine deaminase from rat and rabbit liver and pig brain show that this compound is a powerful inhibitor. The compound has a Ki = 5 micronM for the enzyme from pig brain. The use of the inhibitor for the synthesis of a specific adsorbent for guanine deaminase was studied.