Related Experiment Video

Updated: Mar 29, 2026

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

12.3K

The CXCR2 Gene Polymorphism Is Associated with Stroke in Patients with Essential Hypertension

Yanina R Timasheva1, Timur R Nasibullin1, Olga E Mustafina1

  • 1Institute of Biochemistry and Genetics, USC RAS, Ufa, Russia.

Cerebrovascular Diseases Extra
|December 10, 2015
PubMed

Insights

Genetic variations in inflammatory genes, like CXCR2, influence stroke risk in essential hypertension patients. Specific CXCR2 genotypes were linked to increased or decreased ischemic stroke incidence in this population.

Area of Science:

  • Genetics
  • Cardiovascular Medicine
  • Immunology

Background:

  • Essential hypertension (EH) is a primary risk factor for stroke.
  • Inflammation is a proposed mechanism linking hypertension to stroke.
  • Genetic predisposition plays a role in hypertension and stroke development.

Purpose of the Study:

  • To investigate the association between inflammatory mediator gene polymorphisms and ischemic stroke incidence in essential hypertension patients.
  • To identify specific genetic markers that predict stroke risk in hypertensive individuals.

Main Methods:

  • Case-control study involving 625 ethnic Tatar individuals from Bashkortostan.
  • Genotyping analysis of inflammatory mediator genes, including CXCR2 rs1126579.
  • Statistical analysis to assess the association between polymorphisms and stroke risk, including gene-gene interactions.

Main Results:

  • The CXCR2 rs1126579 polymorphism was significantly associated with ischemic stroke risk in EH patients.
  • Heterozygous carriers of CXCR2 rs1126579 had an increased risk of stroke (OR = 1.72).
  • The CXCR2*C/C genotype demonstrated a protective effect against stroke (OR = 0.32).
  • Gene-gene interaction analysis confirmed the role of CXCR2 rs1126579 in stroke risk.
  • Other inflammatory genes (CCL2, CCL18, CX3CR1, CCR5, CXCL8) showed potential involvement but lacked statistical significance in individual analysis.

Conclusions:

  • The CXCR2 rs1126579 polymorphism is a significant genetic risk factor for ischemic stroke in essential hypertension.
  • Specific CXCR2 genotypes can predict stroke risk, offering potential for targeted prevention strategies.
  • Further research into gene-gene interactions involving inflammatory pathways is warranted for a comprehensive understanding of stroke etiology.

Keywords:
CXCR2ChemokinesEssential hypertensionIschemic stroke

More Related Videos

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene07:00

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene

Published on: April 1, 2019

10.6K
Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model05:32

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model

Published on: August 11, 2023

3.3K

Related Concept Videos

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
109
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
68
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
76
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
19.8K
Regulation of Stroke Volume01:27

Regulation of Stroke Volume

The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
5.7K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.4K