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Myocardial Injury in Children with Unoperated Congenital Heart Diseases

Mohamed O Hafez1, Saed M Morsy1, Ragab A Mahfoz2

  • 1Pediatrics Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.

Cardiology Research and Practice
|December 10, 2015
PubMed

Insights

Myocardial injury is common in children with congenital heart diseases (CHDs). Cardiac troponin I (cTnI) testing can help detect this injury early in both cyanotic and acyanotic CHDs.

Area of Science:

  • Pediatric Cardiology
  • Cardiovascular Research
  • Biomarker Discovery

Background:

  • Congenital heart diseases (CHDs) can lead to myocardial injury due to volume and pressure overload.
  • Children with CHDs are at risk for cardiac damage, necessitating methods for early detection.

Purpose of the Study:

  • To determine the incidence of myocardial injury in children with cyanotic and acyanotic CHDs.
  • To assess the correlation between myocardial injury biomarkers and hemodynamic parameters in pediatric CHDs.

Main Methods:

  • Serum cardiac troponin I (cTnI) levels were measured in 80 children with CHDs and 40 healthy controls.
  • Hemodynamic parameters, including pulmonary to systemic blood flow (Qp/Qs) and pulmonary to systemic arterial pressure (Pp/Ps) ratios, were assessed via cardiac catheterization.

Main Results:

  • Elevated cTnI, indicating myocardial injury, was found in 64 out of 80 (80%) children with CHDs.
  • Serum cTnI levels were significantly higher in both cyanotic and acyanotic CHD groups compared to controls (p < 0.05).
  • cTnI levels showed significant correlations with oxygen saturation (SpO2), ejection fraction (EF), Qp/Qs, and Pp/Ps ratios.

Conclusions:

  • The incidence of myocardial injury is high in children diagnosed with CHDs.
  • Cardiac troponin I (cTnI) assays are valuable tools for the early detection and management of myocardial injury in pediatric CHD patients.

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