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Studies on anti-hyperglycemic effect of Euphorbia antiquorum L. root in diabetic rats
Varadharajan Madhavan1, Anita Murali2, Doppalapudi Sree Lalitha1
1Department of Pharmacognosy, Faculty of Pharmacy, M. S. Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.
Background/Aim:
To determine the anti-hyperglycemic effect of Euphorbia antiquorum L. root.
Materials And Methods:
The study evaluates the anti-hyperglycemic effect of E. antiquorum root in streptozotocin-nicotinamide-induced Type 2 diabetes mellitus and fructose-induced insulin resistance models. Alcohol and aqueous extracts of E. antiquorum root were administered at doses 200 and 400 mg/kg p.o. Serum levels of glucose, total cholesterol, triglycerides, glycosylated hemoglobin (GHb), and hepatic levels of malondialdehyde, glutathione, and glycogen were estimated.
Results:
Treatment with the alcohol and aqueous extracts of E. antiquorum roots resulted in significant (P < 0.001) lowering of serum blood glucose and GHb levels in both the models. Flavonoids, phenolic compounds, and glycosides were detected in the preliminary phytochemical screening.
Conclusion:
Root of E. antiquorum showed promising anti-hyperglycemic effect which may be due to the presence of important phytochemicals.
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