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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Charged Particle Therapy with Mini-Segmented Beams.

F Avraham Dilmanian¹, John G Eley², Adam Rusek³

¹Department of Radiation Oncology, Health Sciences Center, Stony Brook University , Stony Brook, NY , USA ; Department of Neurology, Health Sciences Center, Stony Brook University , Stony Brook, NY , USA ; Department of Radiology, Health Sciences Center, Stony Brook University , Stony Brook, NY , USA.

Frontiers in Oncology

|December 10, 2015

Summary

This summary is machine-generated.

New minibeam techniques using proton and carbon ions can spare healthy tissues during radiation therapy. These methods reduce normal tissue toxicity, potentially improving cancer treatment outcomes by minimizing side effects.

Keywords:

carbon minibeams carbon therapy interleaved carbon minibeams light-ion minibeams light-ion therapy proton minibeams proton therapy tissue-sparing effect

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Area of Science:

Radiation Oncology
Medical Physics
Particle Therapy

Background:

Proton and carbon ion therapy offer superior dose distribution, sparing tissue distal to tumors.
Superficial tissues, like skin, can receive higher doses with conventional particle therapy compared to X-rays.
Novel beam segmentation strategies are needed to further reduce normal tissue toxicity.

Purpose of the Study:

To present and evaluate two novel minibeam radiation therapy techniques.
To demonstrate the potential of these methods for reducing dose to surrounding healthy tissues.
To explore the clinical applicability of interleaved carbon and proton/light ion minibeams.

Main Methods:

Developed 'interleaved carbon minibeams' using two arrays of parallel beams intersecting at the target.
Investigated 'radiosurgery with arrays of proton and light ion minibeams,' considering beam broadening.
Validated methods through synchrotron X-ray experiments, in-vivo rabbit brain ablation study, and Monte Carlo simulations.

Main Results:

Interleaved carbon minibeams successfully ablated a rabbit brain tumor with minimal surrounding tissue damage.
Proton and light ion minibeams showed significant broadening, merging to form a solid beam at depth.
Both techniques demonstrated substantial sparing of proximal normal tissues compared to conventional methods.

Conclusions:

Minibeam radiation therapy, using interleaved carbon or broadening proton/light ion beams, offers significant normal tissue sparing.
These techniques enable precise tumor ablation while minimizing toxicity to superficial and surrounding tissues.
The described methods hold promise for enhanced radiosurgery and improved therapeutic index in particle therapy.