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Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection
11:14

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Published on: November 7, 2018

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[Update Chronic Viral Hepatitis B and C]

Benedetta Terziroli Beretta-Piccoli1, Melanie Schranz1,2, Andrea De Gottardi1,2

  • 11 Epatocentro Ticino, Lugano.

Praxis
|December 10, 2015
PubMed

Insights

Chronic hepatitis B (HBV) infection can persist lifelong, but inactive carrier status is a therapeutic goal. Hepatitis C treatment is recommended for advanced fibrosis, with new direct antivirals offering high efficacy and safety.

Area of Science:

  • Hepatology
  • Virology
  • Immunology

Context:

  • Chronic hepatitis B (HBV) infection presents a complex natural history influenced by infection age, comorbidities, and coinfections.
  • HBV persists lifelong in hepatocytes, making complete viral elimination unachievable.
  • Chronic hepatitis C (HCV) can progress to liver cirrhosis in 30% of cases, necessitating treatment for significant fibrosis.

Purpose:

  • To outline the management of chronic hepatitis B and C.
  • To highlight therapeutic goals and available treatments for HBV.
  • To define treatment indications for HCV based on fibrosis staging.

Summary:

  • HBV infection management aims for inactive carrier status using pegylated interferon or direct antivirals, alongside prophylactic screening and vaccination.
  • HCV treatment is advised for Metavir fibrosis stage 2 or higher, with newer direct-acting antivirals (DAAs) providing short, effective, and safe regimens.

Impact:

  • Effective management strategies can prevent disease progression and improve patient outcomes.
  • Prophylactic measures like vaccination are crucial for controlling HBV transmission.
  • Advances in DAAs have revolutionized HCV treatment, offering high cure rates with minimal side effects.

Keywords:
DAAHepatozelluläres KarzinomImpfungLeberzirrhoseScreeningantiviraux directscarcinome hépatocellulairecirrhosecirrhosishepatocellular carcinomascreeningvaccination

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