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Magnetic resonance imaging in a guinea pig model of inner ear decompression sickness and barotrauma
Nathan E Pierce1, G Joseph Parell1, Reordan O De Jesus2
1Department of Otolaryngology, University of Florida, Gainesville, Florida, U.S.A.
Objectives/Hypothesis:
Scuba diving may cause severe hearing loss and vertigo due to inner ear barotrauma and decompression sickness. These may be difficult to differentiate clinically. Decompression sickness requires costly and potentially dangerous hyperbaric therapy, whereas such treatment may worsen barotrauma. The objective of this study was to assess the potential utility of magnetic resonance imaging to identify and distinguish blood from air in the inner ear, manifestations of barotrauma and decompression sickness, using a guinea pig model.
Study Design:
Prospective animal trial.
Methods:
Magnetic resonance of the head was performed at 3 Tesla, pre- and postinjection of 2, 4, or 10 μL of air or blood through the round window into the perilymph. With this model, 2 μL has been shown to cause hearing loss. Images were reviewed by a neuroradiologist blinded to the treatment.
Results:
All 14 normal ears, five of seven blood- and five of seven air-injected ears, were correctly interpreted. Two blood- and one air-injected ear were interpreted as indeterminate. One air-injected ear was incorrectly interpreted as blood.
Conclusions:
Magnetic resonance reliably distinguishes small volumes of air and blood in the guinea pig inner ear. Magnetic resonance should be evaluated for its utility in the diagnosis of inner ear barotrauma and decompression sickness in scuba divers.
Level Of Evidence:
NA Laryngoscope, 126:2106-2109, 2016.
