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Contact systems in infectious disease.

R W Colman1

  • 1Thrombosis Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140.

Reviews of Infectious Diseases
|May 1, 1989
PubMed
Summary
This summary is machine-generated.

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This review examines contact coagulation pathways activated by foreign surfaces and infections. It highlights the potential of inhibiting these pathways for treating sepsis and viral hemorrhagic fevers.

Area of Science:

  • Biochemistry
  • Hematology
  • Immunology

Background:

  • Contact coagulation pathways are activated when blood encounters foreign surfaces, such as during endothelial damage.
  • Alterations in contact proteins are observed in both natural and experimentally induced human infections.

Purpose of the Study:

  • To review the current understanding of contact coagulation pathways.
  • To summarize changes in contact proteins during infections.
  • To describe the inhibition of contact pathway activation in experimental sepsis.

Main Methods:

  • Literature review of contact coagulation pathways.
  • Summary of studies on contact protein changes in human infections.
  • Description of experiments using mutant alpha 1-antitrypsin to inhibit porcine sepsis.

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Main Results:

  • Foreign surfaces and infections significantly alter contact protein levels.
  • Mutant alpha 1-antitrypsin effectively inhibited contact pathway activation in experimental porcine sepsis.

Conclusions:

  • Understanding contact coagulation pathways is crucial for infection pathogenesis.
  • Inhibiting contact pathway activation shows promise for treating sepsis.
  • These principles may inform the treatment of viral hemorrhagic fevers.