Related Experiment Video

Updated: Jun 16, 2026

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure
15:18

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure

Published on: July 30, 2009

18.8K

Special article: 2014 Pediatric Clinical Trials Forum

Clifford Bogue1, Linda A DiMeglio2, Samuel Maldonado3

  • 1Department of Pediatrics, Yale School of Medicine, Yale-New Haven Children's Hospital, New Haven, Connecticut.

Pediatric Research
|December 10, 2015
PubMed

Insights

A global Pediatric Clinical Trials Network is proposed to accelerate medical advances for children. This network aims to improve the safety and efficacy of pediatric drugs and devices, addressing critical gaps in research.

Area of Science:

  • Pediatric Research
  • Clinical Trials
  • Medical Innovation

Background:

  • Current clinical trial systems face challenges in testing and disseminating drugs and devices for pediatric populations.
  • Inadequate pediatric indications for drugs and devices persist, especially in neonatology and rare diseases.

Purpose of the Study:

  • To discuss the feasibility of establishing an independent global Pediatric Clinical Trials Network.
  • To accelerate medical advances and improve the safety and efficacy of treatments for neonates, infants, children, adolescents, and young adults.

Main Methods:

  • Convening key stakeholders, including the American Academy of Pediatrics, in November 2014.
  • Identifying challenges within existing U.S. and global clinical trial systems for pediatric research.
  • Developing a shared vision and Consensus Statement for a Global Pediatric Clinical Trials Network.

Main Results:

  • Stakeholders mapped a vision for a network to enhance pediatric drug and device development.
  • The proposed network would provide central infrastructure and support for pediatric subspecialties.
  • Strong interest was expressed by participants in forming such a network to address unmet needs.

Conclusions:

  • Attendees resolved to establish a Global Pediatric Clinical Trials Network.
  • Commitment was made to engage in the creation and sustainment of the network.
  • The network aims to facilitate the availability of innovative, high-quality pediatric therapies.

More Related Videos

Guidelines for Elective Pediatric Fiberoptic Intubation11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

18.9K
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

11.5K

Related Concept Videos

Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...