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Hydrolytically Stable Thiol-ene Networks for Flexible Bioelectronics.

Radu Reit1, Daniel Zamorano1, Shelbi Parker1

  • 1Department of Bioengineering, ‡Department of Chemistry, §Department of Materials Science and Engineering, and ∥Department of Mechanical Engineering, The University of Texas at Dallas , 800 West Campbell Road, Mailstop RL 10, Richardson, Texas 75080, United States.

ACS Applied Materials & Interfaces
|December 10, 2015
PubMed
Summary

New polymer networks offer tunable stiffness and stability in alkaline conditions, crucial for implantable bioelectronic medicines (electroceuticals). These advanced materials promise durable flexible bioelectronics for long-term medical applications.

Keywords:
degradableflexible bioelectronicshydrolytic stabilitythiol−enetunable modulus

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Polymer Chemistry

Background:

  • Current polymer networks for bioelectronics lack tunable modulus and hydrolytic stability.
  • Existing materials like polyimides and polysiloxanes offer fixed stiffness, limiting applications.
  • Thiol-ene copolymers show potential but degrade in aqueous environments.

Purpose of the Study:

  • To develop hydrolytically stable polymer networks with tunable elastic modulus.
  • To investigate the mechanical properties of these novel polymer networks.
  • To create robust microelectrodes for long-term implantable bioelectronic devices.

Main Methods:

  • Synthesis of tunable modulus polymer networks.
  • Mechanical characterization of the polymer networks.
  • Fabrication and accelerated aging of microelectrode arrays.

Main Results:

  • Demonstrated hydrolytically stable polymer networks with tunable modulus.
  • Characterized the mechanical behavior of the new network materials.
  • Fabricated microelectrodes that survived harsh accelerated aging conditions.

Conclusions:

  • The developed polymer networks are suitable for harsh alkaline environments, ideal for electroceuticals.
  • Tunable modulus and hydrolytic stability are key advancements for next-generation flexible bioelectronics.
  • The new microelectrodes show enhanced durability for long-term bioelectronic medicine applications.