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Updated: Mar 29, 2026

Polymeric Microneedle Array Fabrication by Photolithography

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

Polymeric Microneedle Array Fabrication by Photolithography.

Himanshu Kathuria¹, Jaspreet Singh Kochhar¹, Michelle Hui Min Fong¹

¹Department of Pharmacy, National University of Singapore.

Journal of Visualized Experiments : Jove

|December 10, 2015

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This summary is machine-generated.

This study details fabricating polymeric microneedle (MN) arrays using photolithography and micro-lenses. The novel mold-free method creates sharp MNs for potential transdermal drug delivery.

Area of Science:

Materials Science
Biomedical Engineering
Drug Delivery

Background:

Microneedle (MN) arrays are promising for transdermal drug delivery.
Fabrication methods often require complex molds.
Controlling MN geometry is crucial for efficacy and safety.

Purpose of the Study:

To develop a simple, mold-free method for fabricating polymeric microneedle arrays.
To investigate the influence of embedded micro-lenses on MN geometry.
To assess the potential of these MN arrays for therapeutic agent delivery.

Main Methods:

Photolithography was employed for MN array fabrication.
A photomask with embedded micro-lenses was utilized in a mold-free process.
Characterization of MN geometry, including tip diameter and length, was performed.

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Polymeric Microneedle Array Fabrication by Photolithography

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Main Results:

Robust polymeric microneedle arrays were successfully fabricated.
Embedded micro-lenses significantly influenced MN geometry, particularly sharpness.
Fabricated MNs exhibited tip diameters between 41.5 µm ± 8.4 µm and 71.6 µm ± 13.7 µm.
MN lengths ranged from 957 µm ± 171 µm to 1,336 µm ± 193 µm.

Conclusions:

A facile, mold-free photolithography technique using micro-lenses enables precise fabrication of polymeric MN arrays.
The developed MN arrays possess suitable dimensions for transdermal delivery applications.
These microneedle arrays show potential for delivering both low molecular and macromolecular therapeutic agents through the skin.