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Related Experiment Videos

The rat as an experimental animal.

T J Gill1, G J Smith, R W Wissler

  • 1University of Pittsburgh School of Medicine, PA 15261.

Science (New York, N.Y.)
|July 21, 1989
PubMed
Summary

Genetically characterized rat strains, particularly their major histocompatibility complex, advance comparative genetics and biomedical research applications. This enhances the rat model

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Area of Science:

  • Genetics and Genomics
  • Immunology
  • Biomedical Research

Background:

  • Recent advancements in characterizing inbred, congenic, and recombinant rat strains.
  • Detailed genetic descriptions, especially of the major histocompatibility complex (MHC).

Purpose of the Study:

  • To highlight the utility of genetically defined rat models in various biomedical research fields.
  • To discuss the application of these models in immunogenetics, transplantation, and disease research.

Main Methods:

  • Review of genetic characterization data for multiple rat strains.
  • Synthesis of research findings utilizing these rat models.

Main Results:

  • Enhanced understanding of rat genetics, including the MHC.
  • Increased applicability of rat models in comparative genetics.

Conclusions:

  • Genetically characterized rat strains are invaluable tools for biomedical research.
  • These models significantly contribute to studies in immunogenetics, transplantation, cancer risk, cardiovascular disease, and behavior.

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