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Updated: Mar 29, 2026

HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL
Published on: April 11, 2011
B Cells Loaded with Synthetic Particulate Antigens: A Versatile Platform To Generate Antigen-Specific Helper T Cells
Antoine Sicard1,2, Alice Koenig1,2, Stéphanie Graff-Dubois3
1International Center for Infectiology Research (CIRI); French National Institute of Health and Medical Research (INSERM) Unit 1111, Claude Bernard Lyon 1 University; Ecole Normale Supérieure de Lyon, CNRS, UMR 5308 , 69007 Lyon, France.
Abstract:
Adoptive cell therapy represents a promising approach for several chronic diseases. This study describes an innovative strategy for biofunctionalization of nanoparticles, allowing the generation of synthetic particulate antigens (SPAg). SPAg activate polyclonal B cells and vectorize noncognate proteins into their endosomes, generating highly efficient stimulators for ex vivo expansion of antigen-specific CD4+ T cells. This method also allows harnessing the ability of B cells to polarize CD4+ T cells into effectors or regulators.
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