Related Experiment Video
Updated: Mar 29, 2026
Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement
Published on: July 29, 2013
Impact of point spread function reconstruction on quantitative 18F-FDG-PET/CT imaging parameters and inter-reader
Sara Sheikhbahaei1, Charles Marcus, Rick Wray
1aRussell H. Morgan Department of Radiology and Radiological Sciences bDepartment of Oncology of Johns Hopkins School of Medicine cDepartment of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Point-spread function (PSF) reconstruction in PET/CT imaging improves standardized uptake values (SUV) but decreases metabolic tumor volume (MTV). This method enhances tumor uptake discernment with excellent inter-reader agreement for oncology patients.
Area of Science:
- Nuclear Medicine
- Medical Imaging
- Oncology
Background:
- Quantitative PET/CT indices are crucial for oncology patient management.
- The impact of point-spread function (PSF) reconstruction on these indices and their reproducibility requires investigation.
Purpose of the Study:
- To evaluate the effect of PSF reconstruction on quantitative PET/CT parameters.
- To assess the inter-reader reproducibility of these measurements with and without PSF.
Main Methods:
- 42 oncology patients with 85 lesions (≥ 2 cm) underwent PET/CT.
- Images were reconstructed with and without PSF.
- Standardized uptake values (SUV), total lesion glycolysis (TLG), and metabolic tumor volume (MTV) were measured by two readers.
Main Results:
- PSF reconstruction significantly increased SUVmax, SUVmean, and SUVpeak.
- PSF reconstruction tended to decrease MTV and had a variable effect on TLG.
- Excellent correlation (ICC ≥ 0.96) and inter-reader agreement (ICC 0.9–1.0) were observed for all parameters.
Conclusions:
- PSF reconstruction improves SUV measurements by better discerning tumor uptake.
- PSF reconstruction leads to lower MTV, potentially impacting treatment response assessment.
- PSF reconstruction offers reliable quantitative PET/CT measurements with high inter-reader reproducibility.
More Related Videos
08:02Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals
Published on: November 15, 2024
09:21Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images
Published on: February 18, 2015