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Incidence and prognosis implications of long term left ventricular reverse remodeling in patients with dilated

Isabel Ruiz-Zamora1, Jorge Rodriguez-Capitan2, Alicia Guerrero-Molina3

  • 1Calahorra Hospital Foundation, La Rioja, Spain.

International Journal of Cardiology
|December 10, 2015
PubMed

Insights

Left ventricular reverse remodeling (LVRR) occurred in over half of dilated cardiomyopathy patients, improving prognosis. Fewer coronary stenoses, milder symptoms, and less mitral regurgitation predict LVRR success.

Area of Science:

  • Cardiology
  • Heart Failure Research

Background:

  • Left ventricular reverse remodeling (LVRR) in dilated cardiomyopathy (DCM) is not well understood with current treatments.
  • Understanding LVRR incidence, predictors, and long-term outcomes is crucial.

Purpose of the Study:

  • To determine the incidence of LVRR in DCM patients.
  • To identify factors predicting LVRR.
  • To assess the long-term prognosis of patients with LVRR.

Main Methods:

  • Retrospective analysis of 387 consecutive DCM outpatients.
  • Mean follow-up of 50.4 months.
  • Statistical analysis to identify predictors of LVRR and prognosis.

Main Results:

  • Sustained LVRR observed in 57.6% of patients.
  • Independent predictors of LVRR included fewer coronary stenoses, lower NYHA Functional Class, and less mitral regurgitation.
  • LVRR and time to achieve it were strong predictors of long-term prognosis.

Conclusions:

  • Sustained LVRR is common in DCM and linked to significantly better outcomes.
  • A simple model including coronary stenosis, NYHA FC, and mitral regurgitation can prognosticate LVRR.
  • Achieving LVRR and the speed of its achievement are critical for long-term prognosis in DCM.
Abstract

Keywords:
Dilated cardiomyopathyPrognosisReverse remodelingVentricle

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