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Taxane anticancer agents: a patent perspective.

Iwao Ojima1,2, Brendan Lichtenthal1, Siyeon Lee2

  • 1a Department of Chemistry , Stony Brook University , Stony Brook , NY 11794-3400 , USA.

Expert Opinion on Therapeutic Patents
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Summary
This summary is machine-generated.

Recent advancements in taxane chemotherapy, including new formulations like nab-paclitaxel, offer improved cancer treatment options. Future developments focus on novel taxanes and targeted drug delivery systems for enhanced efficacy.

Keywords:
abraxanecabazitaxelcancerchemotherapydocetaxeldrug combinationformulation paclitaxeltaxanetaxoid

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Area of Science:

  • Oncology
  • Medicinal Chemistry
  • Drug Development

Background:

  • Paclitaxel and docetaxel are established anticancer drugs.
  • Cabazitaxel (FDA 2010) and nab-paclitaxel (FDA 2005) represent significant advancements in taxane therapy.
  • Nab-paclitaxel combined with gemcitabine received FDA approval in 2013 for pancreatic cancer.

Purpose of the Study:

  • To review patent literature on taxane-based chemotherapies and drug developments from 2010 to early 2015.
  • To identify emerging trends and future directions in taxane anticancer agent research.
  • To provide insights into the next wave of innovation in taxane drug discovery.

Main Methods:

  • Comprehensive review of patent applications filed between 2010 and early 2015.
  • Analysis of various aspects of taxane-based chemotherapy and drug development.
  • Focus on FDA-approved taxane drugs and their therapeutic applications.

Main Results:

  • Significant patent activity in taxane anticancer agents during the review period.
  • Emergence of new nano-formulations inspired by nab-paclitaxel.
  • Continued expansion of therapeutic applications for FDA-approved taxanes.

Conclusions:

  • FDA-approved taxanes will see expanded use via drug combinations and novel formulations.
  • New nano-formulations are a growing trend in taxane drug development.
  • Next-generation, highly potent taxanes are crucial for developing targeted drug delivery systems.