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Updated: Mar 29, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Clinical experience with systemic cyclosporine A treatment in severe childhood psoriasis
Emel Bulbul Baskan1, Serkan Yazici1, Sukran Tunali1
1a Uludag University School of Medicine, Department of Dermatology and Venereology , Bursa , Turkey.
Background:
Severe forms of psoriasis including erythrodermic or pustular psoriasis, which require a more aggressive therapeutic approach such as phototherapy or systemic therapies, are rarely seen. Systemic toxicity and long-term safety of these agents are serious concerns in children.
Objective:
We report our experience on the efficacy and safety of cyclosporine A treatment in 22 patients of childhood psoriasis.
Methods:
We retrospectively analyzed the records of all patients less than 18 years of age treated with systemic cyclosporine A therapy at our clinic between January 2000 and March 2009. Demographic features as well as other relevant data including previous therapies, the dosage and duration of cyclosporine A therapy, response to treatment and side effects were retrieved from the patients' records.
Results:
A total of 22 children were treated with systemic cyclosporine A therapy. Seventeen patients were found to be excellent responders. The mean therapeutic dosage of cyclosporine A was 3.47 ± 0.62 mg/kg/day. The mean duration of cyclosporine A therapy was 5.68 ± 3.29 months. The median time to total clearance of the lesions was 4.0 weeks.
Conclusion:
We conclude that cyclosporine A therapy is equally effective and safe in pediatric psoriasis patients as in adults.
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