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Microbubble oscillating in a microvessel filled with viscous fluid: A finite element modeling study.

Chuyi Chen1, Yuyang Gu1, Juan Tu1

  • 1Key Laboratory of Modern Acoustics (MOE), Department of Physics, Collaborative Innovation Center of Advanced Microstructure, Nanjing University, Nanjing 210093, China.

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|December 15, 2015
PubMed
Summary

The constrained environment of elastic microvessels causes asymmetric oscillations in ultrasound contrast agents (UCAs), potentially damaging vascular cells. Microbubble resonance frequency and shell elasticity are key factors in these dynamics.

Keywords:
Asymmetric deformationBubble–blood–vessel interactionsElastic microvesselEncapsulated microbubblesFinite element method model

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Area of Science:

  • Biomedical Engineering
  • Acoustics
  • Fluid Dynamics

Background:

  • Ultrasound contrast agents (UCAs) are crucial for medical imaging and therapy.
  • Understanding UCA dynamics within elastic microvessels is vital for safe and effective applications.

Purpose of the Study:

  • To investigate the influence of acoustic parameters and material properties on coated-microbubble oscillations in elastic microvessels.
  • To analyze the resulting bubble-blood-vessel system interactions and their potential for causing cellular damage.

Main Methods:

  • A two-dimensional (2D) asymmetric finite element model was employed for numerical simulations.
  • The study examined the effects of acoustic pressure, frequency, vessel size, fluid viscosity, and microbubble shell properties.

Main Results:

  • Vessel constraints induce asymmetric bubble oscillations and vessel deformation, shifting resonance frequency higher.
  • High shear stress (up to 26.95 kPa) can be generated on vessel walls, potentially damaging endothelial cells.
  • Asymmetric oscillation ratios increase with acoustic pressure and blood viscosity, or decreased vessel size and shell elasticity.

Conclusions:

  • Microbubble resonance frequency and UCA shell elasticity significantly influence bubble-blood-vessel system dynamics.
  • The findings highlight the importance of considering microvessel constraints and material properties for UCA applications.
  • Simulations indicate potential for vascular damage under specific acoustic driving and material conditions.