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Total ocular surface amniotic membrane transplantation for paraquat-induced ocular surface injury
Ting Wang1, Changsen Liang1, Xiaohan Xu1
1Shandong Eye Hospital, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao, China.
Objective:
To evaluate the therapeutic efficacy of modified amniotic membrane transplantation (MAMT) for paraquat-induced ocular surface injury.
Design:
Retrospective case series.
Participants:
Thirty patients (30 eyes) with paraquat-induced ocular surface injury.
Methods:
Among the patients, 8 underwent MAMT, 14 received conventional amniotic membrane transplantation (AMT), and 8 were treated with simple drug therapy (DT). Features related to the damage, corneal epithelial defect closure time, visual acuity, stromal haze, and complications were recorded.
Results:
In the MAMT and AMT groups, visual acuity in all eyes recovered to the preinjury level; in the DT group, visual acuity in 3 eyes (37.5%) recovered to the preinjury level. The mean corneal epithelial defect closure time was 7.6 ± 2.7 days in the MAMT group, 9.8 ± 3.6 days in the AMT group, and 18.2 ± 5.2 days in the DT group (p < 0.05). There was a significant difference in the symblepharon rate after treatment among the 3 groups (MAMT: 0%, AMT: 35.7%, DT: 87.5%; p < 0.05). Although the tear secretion was reduced in all groups, it was significantly lower in the DT group compared with the MAMT and AMT groups (p < 0.05).
Conclusions:
Paraquat-induced ocular injuries can lead to whole ocular surface damage. MAMT treatment in a timely manner can effectively promote the repair of the ocular surface and reduce the complications from symblepharon.
Insights
Modified amniotic membrane transplantation (MAMT) effectively treats paraquat-induced ocular surface injury, promoting faster healing and reducing complications like symblepharon compared to conventional treatments.
Area of Science:
- Ophthalmology
- Regenerative Medicine
- Toxicology
Background:
- Paraquat ingestion can cause severe ocular surface damage.
- Ocular surface injuries require effective therapeutic interventions to restore vision and prevent complications.
Purpose of the Study:
- To evaluate the therapeutic efficacy of modified amniotic membrane transplantation (MAMT) for paraquat-induced ocular surface injury.
Main Methods:
- Retrospective case series involving 30 patients with paraquat-induced ocular surface injury.
- Comparison of MAMT, conventional amniotic membrane transplantation (AMT), and drug therapy (DT).
- Assessment of corneal epithelial defect closure time, visual acuity, stromal haze, tear secretion, and complications.
Main Results:
- MAMT and AMT groups showed complete visual acuity recovery; 37.5% in the DT group recovered.
- Corneal epithelial defect closure was fastest in the MAMT group (7.6 days) compared to AMT (9.8 days) and DT (18.2 days).
- MAMT resulted in a 0% symblepharon rate, significantly lower than AMT (35.7%) and DT (87.5%).
Conclusions:
- Modified amniotic membrane transplantation (MAMT) is an effective treatment for paraquat-induced ocular surface damage.
- Timely MAMT promotes ocular surface repair and significantly reduces symblepharon formation.
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