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Updated: Mar 29, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
New sesquiterpene and thiophene derivatives from Artemisia rupestris
Chen Zhang1, Bing-Yu Liu1, Ke-Wu Zeng1
1a State Key Laboratory of Natural and Biomimetic Drugs , School of Pharmaceutical Sciences, Peking University , Beijing 100191 , China.
Abstract:
A new sesquiterpene, rupestrisin A (1), and three new thiophene derivatives, rupestrienes A-C (2-4), were isolated from Artemisia rupestris. Their structures were determined by analyses of MS and NMR spectroscopic data, and the absolute configuration of 1 was established by calculated ECD spectra using time-dependent density functional theory. In in vitro bioassays, compounds 1-4 showed inhibitory effects on LPS-stimulated NO production in BV-2 microglial cells with IC50 values of 24.3, 20.3, 8.5, and 5.3 μM, respectively.
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