Related Experiment Video
Updated: Mar 29, 2026

Characterization of Amyloid Structures in Aging C. Elegans Using Fluorescence Lifetime Imaging
Published on: March 27, 2020
Association-dissociation process with aging subunits: Recursive solution
Thomas Niedermayer1, Reinhard Lipowsky1
1Department of Theory and Bio-Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany.
Abstract:
The coupling of stochastic growth and shrinkage of one-dimensional structures to random aging of the constituting subunits defines the simple association-dissociation-aging process which captures the essential features of the nonequilibrium assembly of cytoskeletal filaments. Because of correlations, previously employed mean-field methods fail to correctly describe filament growth. We study an alternative formulation of the full master equation of the stochastic process. An ansatz for the steady-state solution leads to a recursion relation which allows for the calculation of all emergent quantities with increasing accuracy and in excellent agreement with stochastic simulations.
More Related Videos
14:57Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
Published on: March 23, 2011
09:29Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications
Published on: May 18, 2017
Related Concept Videos
Cooperative Allosteric Transitions
Protein Complex Assembly
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Actin Filament Depolymerization
In F-actin, the ADF/cofilin proteins...
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Disassembly of Intermediate Filaments
Keratin proteins, found at the cell periphery near cell junctions, undergo a cycle of assembly and disassembly. In Type...
Ionic Association