Related Experiment Video
Updated: Mar 29, 2026

Experimental Human Pneumococcal Carriage
Published on: February 15, 2013
Pneumococcal conjugate vaccine use in adults
Raul E Isturiz1, Beate Schmoele-Thoma2, Daniel A Scott3
1a Pfizer Inc , Collegeville , PA , USA.
Abstract:
Streptococcus pneumoniae is a leading cause of illness and death in adults. A polysaccharide vaccine has been available for over 30 years, but despite significant use, the public health impact of this vaccine has been limited. The 13-valent pneumococcal conjugate vaccine (PCV13) has been licensed by the US Food and Drug Administration and other international regulatory authorities with the assumption that induction of a T cell-dependent immune response and noninferior immunogenicity to vaccine antigens when compared with the polysaccharide vaccine would be important to satisfy a significant unmet medical need. PCV13 efficacy against vaccine-type pneumococcal community-acquired pneumonia was confirmed in a large randomized controlled trial in older adults and its use is now increasingly recommended globally.
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