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Amplification of Near Full-length HIV-1 Proviruses for Next-Generation Sequencing
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Population genomics of intrapatient HIV-1 evolution

Fabio Zanini1, Johanna Brodin2, Lina Thebo2

  • 1Evolutionary Dynamics and Biophysics, Max Planck Institute for Developmental Biology, Tübingen, Germany.

Elife
|December 15, 2015
PubMed
Summary

Human immunodeficiency virus (HIV) evolution was tracked using genome-wide sequencing in untreated patients. Findings reveal reproducible diversity patterns and frequent reversions, indicating universal fitness costs and recombination

Keywords:
HIV-1deep sequencingevolutionevolutionary biologyfitness landscapesgenomicsinfectious diseasemicrobiologyreversionviruses

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