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Methotrexate pharmacokinetic genetic variants are associated with outcome in rheumatoid arthritis patients
Patricia Moya1,2, Juliana Salazar3,4, María Jesús Arranz5
1Internal Medicine Department, Hospital de la Santa Creu i Sant Pau, Barcelona.
Background:
Methotrexate (MTX) is the most used drug for the treatment of rheumatoid arthritis (RA) although outcome differs among patients.
Aim:
To evaluate whether polymorphisms in pharmacokinetic genes are associated with outcome in RA patients receiving MTX.
Patients & Methods:
We analyzed 28 SNPs in SLC19A1/RFC1, ABCB1, FPGS and GGH genes.
Results:
We studied 194 RA patients receiving MTX monotherapy. Two FPGS SNPs, rs10987742 and rs10106, were associated with response (p = 0.033 and p = 0.041, respectively). The FPGS rs10106 variant was also associated with MTX survival (p = 0.005) and toxicity (p = 0.021). Three ABCB1 SNPs, rs868755, rs10280623 and rs1858923, were associated with toxicity (p = 0.025, p = 0.048 and p = 0.031, respectively).
Conclusion:
FPGS and ABCB1 genetic variants can influence the outcome in RA patients receiving MTX monotherapy.
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