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Intravitreal memantine retinal toxicity in rabbits.

D Moreno Páramo1, S Reyna Vielma1, A Rodríguez Reyes2

  • 1Servicio de Retina, Hospital General de México, México, D.F., México.

Archivos De La Sociedad Espanola De Oftalmologia
|December 15, 2015
PubMed
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Intravitreal memantine at 70 and 150 ng/ml is safe for rabbit retinas. Higher doses (400 ng/ml) caused retinal structural changes, indicating potential toxicity.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Toxicology

Background:

  • Memantine is an NMDA receptor antagonist with potential therapeutic applications.
  • Evaluating the safety of intravitreal drug delivery is crucial for ocular treatments.

Purpose of the Study:

  • To histologically assess the retinal toxicity of intravitreal memantine in a rabbit model.
  • To determine safe dosage ranges for potential ocular applications of memantine.

Main Methods:

  • A study involving 16 New Zealand rabbits divided into four groups.
  • Intravitreal administration of varying memantine doses (70, 150, 400 ng/ml) or balanced salt solution.
  • Histopathological analysis of enucleated eyes at 15 and 30 days post-injection.

Main Results:

Keywords:
ConejosIntravitrealIntravítreaMemantinaMemantineNMDA receptorRabbitsReceptor NMDARetinaToxicidadToxicity

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  • No significant histopathological changes were observed in retinas treated with 70 ng/ml or 150 ng/ml memantine.
  • Retinal structural changes, specifically in the photoreceptor layer, were noted in eyes treated with 400 ng/ml memantine.
  • Control groups receiving balanced salt solution showed no adverse effects.

Conclusions:

  • Intravitreal memantine at concentrations of 70 ng/ml and 150 ng/ml appears safe in rabbit retinas.
  • A dose of 400 ng/ml of intravitreal memantine induced retinal toxicity, evidenced by structural changes.
  • Further research is warranted to explore the clinical utility and safety profile of memantine in ophthalmology.