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Related Experiment Video

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Cognitive Flexibility: A Default Network and Basal Ganglia Connectivity Perspective.

Deniz Vatansever1,2, Anne E Manktelow1,2, Barbara J Sahakian3

  • 11 Division of Anaesthesia, Department of Medicine, University of Cambridge , Cambridge Biomedical Campus, Cambridge, United Kingdom .

Brain Connectivity
|December 15, 2015
PubMed
Summary

Cognitive flexibility, essential for adapting behavior, is linked to brain network connectivity. Enhanced default mode network (DMN) connectivity with the basal ganglia in healthy adults correlates with better performance on cognitive flexibility tasks.

Keywords:
basal gangliacognitive flexibilitydefault mode networkfunctional connectivityintra/extradimensional set-shiftingstriatum

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neuroimaging

Background:

  • Cognitive flexibility, assessed by the intra/extradimensional set-shifting task (IED), involves shifting attention within a context.
  • Impairments in cognitive flexibility are observed in conditions like schizophrenia and Parkinson's disease, implicating corticostriatal circuits.
  • The default mode network (DMN), including medial prefrontal and posterior cingulate cortices, is increasingly associated with set-shifting, though its direct link to cognitive flexibility needs clarification.

Purpose of the Study:

  • To investigate the relationship between resting-state functional connectivity of the DMN and performance on the IED task in healthy individuals.
  • To establish a definitive link between DMN connectivity and cognitive flexibility.

Main Methods:

  • Resting-state functional magnetic resonance imaging (fMRI) was used to measure DMN functional connectivity.
  • Participants' performance on the intra/extradimensional set-shifting task (IED) was assessed outside the scanner.
  • Correlational analysis was performed between DMN connectivity measures and IED task performance.

Main Results:

  • Greater functional connectivity between the posterior cingulate cortex/precuneus (part of the DMN) and the ventromedial striatopallidum at rest was observed.
  • This enhanced connectivity correlated with fewer total adjusted errors on the IED task, indicating better cognitive flexibility.

Conclusions:

  • A significant relationship exists between DMN connectivity and basal ganglia connectivity concerning cognitive flexibility.
  • These findings highlight the DMN's potential role in supporting adaptive human cognition and executive functions.