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Methods to Inhibit Bacterial Pyomelanin Production and Determine the Corresponding Increase in Sensitivity to Oxidative Stress
Published on: August 31, 2015
Novel inhibitors of the methicillin-resistant Staphylococcus aureus (MRSA)-pyruvate kinase
Mardia Telep El-Sayed1, Roya Zoraghi2, Neil Reiner2
1a Department of Pharmaceutical Chemistry , Institute of Pharmacy, Martin Luther University , Halle , Germany .
Abstract:
Novel bisindolyl-cycloalkane indoles resulted from the reaction of aliphatic dialdehydes and indole. As bisindolyl-natural alkaloid compounds have recently been reported as inhibitors of the methicillin-resistant Staphylococcus aureus (MRSA)-pyruvate kinase (PK), we tested our novel compounds as MRSA PK inhibitors and now report first inhibiting activities. We discuss structure-activity relationships of structurally varied compounds. Activity influencing substituents have been characterized and relations to antibacterial activities of the most active compounds have been proved.
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