Assessment of trace elements levels in patients with Type 2 diabetes using multivariate statistical analysis.
Summary
Type 2 diabetes (T2D) patients show altered levels of key trace elements like zinc, copper, and iron. These changes, analyzed using advanced statistics, suggest a role for trace element metabolism in diabetes development.
Area of Science:
- Endocrinology and Metabolism
- Trace Element Research
- Biochemistry
Background:
- Trace element metabolism is implicated in diabetes mellitus pathogenesis.
- Rising global Type 2 diabetes (T2D) prevalence necessitates understanding contributing factors.
- Specific roles of serum trace elements in T2D progression require investigation.
Purpose of the Study:
- To assess serum trace element levels and their inter-relationships in Type 2 diabetic patients.
- To compare trace element profiles between T2D patients and healthy individuals.
- To identify key trace elements associated with Type 2 diabetes.
Main Methods:
- Inductively coupled plasma mass spectrometry (ICP-MS) analyzed 24 trace elements in serum.
- Multivariate statistical analyses, including correlation, cluster analysis (CA), and principal component analysis (PCA), were employed.
- Study included 40 Egyptian Type 2 diabetic patients and 36 healthy controls.
Main Results:
- Significant differences in fasting blood glucose (FBG) and eight trace elements (Zn, Cu, Se, Fe, Mn, Cr, Mg, As) were observed in T2D patients.
- Multivariate analysis revealed distinct clustering patterns of trace elements in T2D patients.
- PCA highlighted Mg, Fe, Cu, and Zn as crucial factors associated with Type 2 diabetes.
Conclusions:
- Alterations in essential trace metals, particularly Mg, Fe, Cu, and Zn, may contribute to Type 2 diabetes development.
- Multivariate statistical analysis effectively identifies trace element contributors and their correlations in T2D.
- Understanding trace element metabolism offers insights into diabetes mellitus pathogenesis.
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