Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The first experimental diabetes mellitus.

F S Keck1, E F Pfeiffer

  • 1Abteilung Innere Medizin I, Medizinische Klinik und Poliklinik der Universität, Ulm, FRG.

Acta Diabetologica Latina
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Self-monitoring of blood glucose compared with continuous tissue glucose measurement.

Diabetes care·1997
Same author

Statistical approach for evolutionary relationship of alpha-conotoxins and members of insulin-superfamily.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·1996
Same author

Does fall in tissue glucose precede fall in blood glucose?

Diabetologia·1996
Same author

[Glucose sensors in tissue, glucose monitoring and controlled insulin administration].

Medizinische Klinik (Munich, Germany : 1983)·1996
Same author

Subcutaneous glucose concentration in humans. Real estimation and continuous monitoring.

Diabetes care·1995
Same author

Quality control of intensified insulin therapy: HbA1 versus blood glucose.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·1994

Johann Conrad Brunner induced temporary diabetes mellitus in dogs 200 years before Minkowski and von Mering. His experiment involved subtotal pancreatectomy, a procedure now understood to cause reversible diabetes.

Area of Science:

  • Endocrinology
  • History of Medicine
  • Surgical Research

Background:

  • The historical account of surgically induced experimental diabetes typically credits Minkowski and von Mering (1889).
  • However, Johann Conrad Brunner (1653-1727) had previously induced temporary diabetes mellitus in canine subjects approximately 200 years earlier.
  • Brunner's experiments predated the established timeline of diabetes research.

Discussion:

  • Brunner's procedure likely involved subtotal pancreatectomy with reversible traumatic damage to the remaining pancreatic endocrine tissue.
  • The symptoms observed by Brunner were not recognized as diabetes mellitus at the time.
  • This oversight may have altered the trajectory of diabetes research.

Key Insights:

  • Johann Conrad Brunner's early experiments represent the first documented instance of surgically induced temporary diabetes mellitus.

Related Experiment Videos

  • The significance of Brunner's findings was unrecognized due to the lack of association with diabetes symptoms.
  • Revisiting historical experiments offers new perspectives on the evolution of medical understanding.

    • Outlook:

    • Further investigation into Brunner's experimental methods and observations could provide deeper insights into early pancreatic research.
    • Recognizing historical contributions can enrich the narrative of diabetes mellitus research.
    • This historical context underscores the cumulative nature of scientific discovery.