[Early-stage lung cancer manifested as ground-glass opacity]

The incidence of ground-glass opacity (GGO)-dominant lung cancer is rising in China. The review is focused on the diagnosis and therapy for GGO-dominant lung cancer. CT screening in high-risk groups is recommended for early diagnosis of GGO-dominant lung cancer. The early diagnosis of GGO-dominant lung cancer depends on dynamic observation on the chest CT. Non-surgical biopsy or PET/CT has limited diagnostic value in GGO-dominant lung cancer. Video-assisted Thoracoscopic resection (VATS) is the mainstream treatment for GGO-dominant lung cancer. Single-port VATS, VATS segmentectomy, robot-assisted VATS, and subxiphoid VATS are the new directions of minimally invasive surgery. GGO intraoperative localization can be integrated using a variety of models. Sublobectomy could be used in the therapy for adenocarcinoma in situ, minimally invasive adenocarcinoma or pure GGO with 2.0 cm or less in diameter. Surgery for multiple GGO need an individualized strategy.