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RAS-MAPK in ALK targeted therapy resistance

Gorjan Hrustanovic1,2, Trever G Bivona1,2

  • 1a Department of Medicine ; University of California at San Francisco ; San Francisco , CA USA.

Cell Cycle (Georgetown, Tex.)
|December 15, 2015
PubMed

Insights

Resistance limits ALK targeted therapy. Targeting ALK and MEK pathways together improved responses and prevented resistance in ALK-positive lung cancer models, suggesting a new treatment strategy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • Anaplastic Lymphoma Kinase (ALK) targeted therapy is a key treatment for ALK gene rearrangement positive (ALK+) lung adenocarcinoma.
  • Clinical efficacy of ALK inhibitors is often compromised by the development of drug resistance.
  • Understanding the molecular mechanisms driving ALK+ tumor cell survival is crucial for developing effective co-targeting strategies.
Keywords:
ALKMAPKMEKRASlung cancerpolytherapyresistance

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