Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Re-expansion, re-oxygenation, and rethinking.

R M Jackson1, C F Veal

  • 1Birmingham VA Medical Center, Alabama.

The American Journal of the Medical Sciences
|July 1, 1989
PubMed
Summary

Re-expansion pulmonary edema (RPE), first described in 1902, involves lung injury due to re-oxygenation after fluid removal. Recent studies reveal cellular and biochemical mechanisms similar to reperfusion injuries in other organs.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mesencephalic astrocyte-derived neurotropic factor is an important factor in chondrocyte ER homeostasis.

Cell stress & chaperones·2018
Same author

Redox signalling to nuclear regulatory proteins by reactive oxygen species contributes to oestrogen-induced growth of breast cancer cells.

British journal of cancer·2015
Same author

The Poisson Index: a new probabilistic model for protein ligand binding site similarity.

Bioinformatics (Oxford, England)·2007
Same author

New opportunities for protease ligand-binding site comparisons using SitesBase.

Biochemical Society transactions·2007
Same author

Diversity in the SH2 domain family phosphotyrosyl peptide binding site.

Protein engineering·2003
Same author

Predicting function from structure: examples of the serine protease inhibitor canonical loop conformation found in extracellular proteins.

Computers & chemistry·2002

Area of Science:

  • Pulmonary Medicine
  • Pathophysiology
  • Medical History

Background:

  • Re-expansion pulmonary edema (RPE) is a rare complication following thoracentesis.
  • First described by Riesman in 1902 as "albuminous expectoration."
  • Recent research elucidates cellular and biochemical mechanisms of lung injury in RPE.

Purpose of the Study:

  • To review the pathophysiology and biochemical mechanisms of re-expansion pulmonary edema.
  • To highlight the similarities between RPE and acute respiratory distress syndrome (ARDS).
  • To explore the analogy between RPE and other re-oxygenation (reperfusion) injuries.

Main Methods:

  • Literature review of historical and recent studies on RPE.
  • Pathophysiological comparison of RPE with ARDS.
  • Biochemical analysis of mechanisms involved in lung injury during re-expansion.

Main Results:

  • RPE involves intra-alveolar neutrophil activation and increased lung capillary permeability, similar to ARDS.
  • Biochemical pathways in RPE resemble those in reperfusion injuries of other organs.
  • Excessive superoxide production in re-oxygenated lung tissue, despite low xanthine oxidase levels, suggests novel oxidant sources.

Conclusions:

  • RPE is a form of lung-specific re-oxygenation injury.
  • Understanding RPE mechanisms offers insights into broader reperfusion injury syndromes.
  • Further research is needed to fully elucidate the biochemical basis of RPE-induced lung injury.

Related Experiment Videos