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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
Published on: April 10, 2018
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Long noncoding RNAs in aging and age-related diseases
Sukhleen Kour1, Pramod C Rath1
1Molecular Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India.
Ageing Research Reviews
|December 15, 2015
Summary
Aging involves declining physiological functions, with long noncoding RNAs (lncRNAs) emerging as key regulators. This study explores lncRNAs
Area of Science:
- Molecular Biology
- Genetics
- Gerontology
Background:
- Aging is a complex biological process marked by declining physiological functions and increased risk for diseases.
- Altered mRNA and protein levels are known contributors to aging.
- Noncoding RNAs (ncRNAs), including small ncRNAs (sncRNAs) and long ncRNAs (lncRNAs), are newly recognized regulators in biological processes.
Purpose of the Study:
- To explore the role of long noncoding RNAs (lncRNAs) in the aging process and age-related diseases.
- To highlight known and novel lncRNAs implicated in aging.
- To stimulate further research into ncRNAs and aging.
Main Methods:
- Literature review and analysis of existing studies on lncRNAs and aging.
- Identification and description of specific lncRNAs involved in aging.
- Discussion of the potential regulatory functions of lncRNAs in aging.
Main Results:
- lncRNAs represent a significant class of regulators in genomic functions.
- Several known and novel lncRNAs have been identified as playing roles in aging and age-related diseases.
- The functions of lncRNAs in aging are less explored compared to sncRNAs.
Conclusions:
- lncRNAs are emerging as critical players in the aging process and associated pathologies.
- Further investigation into lncRNAs offers a new dimension for understanding aging mechanisms.
- This work encourages expanded research on the involvement of ncRNAs in aging.
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