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Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 BSL-3 Conditions
Published on: September 10, 2021
Fatal case of acute gastroenteritis with multiple viral coinfections
Julien Lupo1, Christine Morel-Baccard2, Anne-Pascale Michard-Lenoir3
1Laboratory of Virology, University Hospital of Grenoble, Grenoble, France; CNRS, Unit for Virus Host-Cell Interactions, 38042 Grenoble, France; Université Grenoble Alpes, Unit for Virus Host-Cell Interactions, 38042 Grenoble, France.
Abstract:
We report a fatal case of acute gastroenteritis in a child with autism spectrum disorder. Multiple viral coinfections were detected by PCR in the patient's stool and digestive biopsy specimens. As viral detection is not necessarily associated with symptomatic disease, a semi-quantitative approach using cycle treshold values was proposed for the clinical interpretation of PCR. We discuss whether concomitant viral infections could be a risk factor for severe outcome in gastroenteritis cases. Individual risk factors are also addressed.
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