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[Nephroblastoma and xeroderma pigmentosum: A rare association]
F Lahlimi1, M Harif1, J Elhoudzi1
1Unité d'hématologie et d'oncologie pédiatrique, service d'hématologie, centre d'oncologie et d'hématologie, CHU Mohammed VI, faculté de médecine et de pharmacie de Marrakech, Amerchich, 40000 Marrakech, Maroc.
This case study highlights the rare occurrence of xeroderma pigmentosum (XP) and Wilms tumor in a pediatric patient. Management of these co-occurring conditions presents significant challenges.
Area of Science:
- Genetics and Molecular Biology
- Pediatric Oncology
- Dermatology
Background:
- Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder characterized by defective DNA repair, leading to increased skin cancer risk.
- The underlying defect involves nucleotide excision repair, impairing the body's ability to fix UV-damaged DNA.
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