Feasibility study design and methods for Project GEMS: Guidelines for Exercise in Multiple Sclerosis

Area of Science:

• Neurology
• Rehabilitation Medicine
• Exercise Science

Background:

• Multiple Sclerosis (MS) significantly impacts quality of life and daily functioning.
• Evidence-based exercise interventions are needed to manage MS symptoms.
• Home-based programs offer accessibility for individuals with mobility challenges.

Purpose of the Study:

• To evaluate the feasibility of the Guidelines for Exercise in Multiple Sclerosis (GEMS) program.
• To assess the GEMS program's potential efficacy in improving symptoms and HRQOL in adults with MS.
• To inform the design of larger randomized controlled trials (RCTs) for home-based exercise in MS.

Main Methods:

• A randomized controlled trial (RCT) design comparing an intervention group to a waitlist control group.
• Participants with mild-to-moderate MS disability completed 4-month home-based exercise programs.
• Feasibility assessed across process, resource, management, and scientific outcome domains.

Main Results:

• The GEMS program demonstrated feasibility across multiple domains, including recruitment, retention, and adherence.
• Home-based exercise, incorporating aerobic and resistance training, was well-tolerated.
• Participant feedback indicated positive engagement with program components like newsletters and video-chats.

Conclusions:

• The GEMS program is a feasible home-based exercise intervention for adults with MS.
• This study provides a foundation for future efficacy and effectiveness trials.
• Home-based exercise holds promise for improving MS symptoms and health-related quality of life.